Preparation and Characterization of Green Curcumin Loaded Polyglycerol Polymeric Nanoparticles: Stability and Molecular Docking

Author : Rania Hassan Hussein Ahmed, Mahmoud E. Soliman, Sherif F. Hammad, Hesham S. M. Soliman, Ahmed Abdel - Mawgood

Abstract :Polymeric based drug delivery systems emerged as a promising approach in drug loading means to maximize drug bioavailability and lessen its accidental effects. Inflammatory diseases which affect millions worldwide can be controlled by anti-inflammatory drugs as curcumin. While curcumin is recognized for its potent anti-inflammatory properties, its efficacy is limited by the extremely low water solubility (0.6 µg/ml) and bioavailability. Polymeric formulations effectively overcome these challenges by creating a sustained-release system that improves drug retention based on the larger size of the polymeric loaded drug in comparison to the free drug, ensures more consistent delivery because of the extended-release profile of the produced particles, and enhances therapeutic efficacy by size dependent internalization of nano range particles. The aim of this work is to establish a green, more advantageous and reliable polymeric delivery system that can be used for curcumin loading as polymeric nanoparticles at the adjusted size (100 to 200) for cell internalization.

Keywords :BTK inhibitor, Curcumin, Nanoparticles, Polymeric system, Solubilization.

Conference Name :International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS-25)

Conference Place Alexandria, Egypt

Conference Date 17th Jun 2025