Synthesis Of Pyrano-Pyrrazole And Pyrano-Pyrimidine Structure

Author : Samira BAAZIZ, Lamouri HAMMAL

Abstract :Pyrazoles and pyrimidines represent an important class of nitrogen heterocycle in organic chemistry, given their large biological potential. 1,2,3. Pyrone is present in a large number of bioactive molecules having diverse biological activities such as anti-viral broad-spectrum anti-bacterial and anti-fungal activities. 2-pyrones are reported to be effective against Alzheimer’s amyloid toxicity. Many chlorinated 2-pyrone based derivatives were discovered as potent anti-cancer agents4. We present in this work the synthesis of a pyrimidine derivative 3 and a pyrazole derivative 4from the intermediate 2(obtained by condensation of ferrocene carboxaldehyde and dehydroacetic acid 1). Compound 3 is obtained by the action of guanidine carbonate on chalcone 2. Compound 4was obtained by the action of phenyl hydrazine on compound 2, the intermediate obtained is oxidized with iodobenzene acetate.

Keywords :Pyrrazole; Pyrimidine; Dehydroacetic acid; Pyrone, Electrochemical and luminescent properties.

Conference Name :International Conference on Molecular Biology, Biochemistry and Biotechnology (ICMBBB-24)

Conference Place Istanbul, Turkey

Conference Date 16th Dec 2024