Discovery of diterpenoids from Isodon serra against leukemia cell.

Author : Kangrui Ji

Abstract : Diterpenoids occupy an important slot of the natural products diversity space with wide ranges of bioactivities and complex structures, providing potential applications for the development of therapeutics. In this study, we reported five diterpenes (+)-15-hydroxysalvinolone (1), 11,12,15 trihydroxy-8,11,13-abietatrien-7-one (2) graciliflorin F (3) gerardianin C (4) and graciliflorin A (5) isolated from Isodon serra (I. serra). Their structures were established by spectroscopic data analysis. All the compounds showed cytotoxicity against human immortalized cell line derived from a patient with chronic myelogenous leukemia (CML) K562 at 20 μM, the inhibition for compound 1, 2, 3, 4 and 5 were 52.66, 61.49, 67.49, 62.54 and 63.79%.

Keywords : Isodon serra, diterpenes, leukemia, cytotoxicity.

Conference Name : International Symposium on Chemistry Of Natural Products (ISCN-26)

Conference Place : Linz, Austria

Conference Date : 2nd Apr 2026