Short- and Long-Term Risks of Incident Heart Failure and Mortality in Hospitalized Patients With COPD-Related Pulmonary Hypertension

Author : Ting Chia Chang, Wei-Ting Chang

Abstract : Introduction: The impact of COPD-related pulmonary hypertension on the subsequent development of heart failure (HF) in patients without pre-existing HF remains unclear. Methods: We conducted a nationwide retrospective cohort study using Taiwan’s National Health Insurance Research Database, including hospitalized COPD patients from 2009 to 2018. Patients with newly diagnosed COPD-related pulmonary hypertension were propensity score–matched (1:4) with COPD patients without pulmonary hypertension. Individuals with prior HF were excluded. The risks of incident HF and all-cause mortality were assessed at 1-, 3-, and 5-year follow-up using Cox proportional hazards and competing risk models. Results: After matching, 2,661 patients with COPD-related pulmonary hypertension and 10,644 controls were analyzed. Patients with pulmonary hypertension had significantly higher risks of incident HF at 1 year (11.73% vs. 8.49%), 3 years (18.67% vs. 13.56%), and 5 years (21.83% vs. 16.43%) (all P < 0.0001). Mortality was also consistently higher at 1, 3, and 5 years compared with controls (all P < 0.0001). These associations remained significant in competing risk analyses accounting for death.Conclusions: COPD-related pulmonary hypertension was associated with increased short- and long term risks of incident HF and mortality among hospitalized COPD patients without prior HF.

Keywords : Chronic obstructive pulmonary disease; Pulmonary hypertension; Incident heart failure.

Conference Name : International Conference on Pulmonary and Respiratory Medicine (ICOPRM - 25)

Conference Place : Jakarta Raya, Indonesia

Conference Date : 27th Dec 2025