Hyperhomocysteinemia and Crohn’s disease in Algeria people

Author : Sakina Zerizer, Hiba Rahma Khellafi, Sarra Farhi, Boutheyna Aribi, Saber Massaoudi

Abstract :Background: Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, are chronic immune-mediated inflammatory diseases of the intestinal tract. Under low vitamin B conditions, homocysteine accumulates and leads to hyperhomocysteinemia which aggravate the pathogenesis of inflammatory bowel disease. Purpose: Our work is to study the effect of hyperhomocysteinemia on Crohn’s disease in Algeria people. Method: This study was carried in symptomatic patients with Crohn’s disease (n=22) at IBAN BADIS Hospital in Algeria and compared to a control group. Homocysteine, CRP and hemoglobin levels were measured and histological sections of intestinal tissue were examined. Results: The results showed that homocysteine (15,54 ±1,29 µmol/l) is increased in patients but not significantly when compared to the control group, the C-reactive protein (21,41 ±34,69 mg/l) is increased also in patients and the concentration of hemoglobin (11,85 ±0,47 g/dl) is decreased very

Keywords :inflammatory

Conference Name :International Conference on Cell Biology, Structures and Processes (ICCBSP-25)

Conference Place Bristol, England

Conference Date 14th Oct 2025