NeuroG1 expression in neuroendocrine phenotype of A549 lung adenocarcinoma cells

Author : Laura Cristina Berumen, Salinas Ka, Caraveo D, Escobar-cabrera J, Mendieta I, García-alcocer G

Abstract :NeuroG1 is a basic helix-loop-helix transcription factor involved in neural differentiation, which inhibits neural stem cells from astrocyte differentiation by its interaction with CBP-Smad1 and from gliogenesis by its interaction with STAT factors. NeuroG1 methylation has been reported in lung adenocarcinoma; furthermore, high NEUROG1 expression has been correlated with markedly shorter overall survival in a phase 2 trial for combination of camrelizumab, carboplatin and Nab-paclitaxel. Nevertheless, there are few reports for lung cancer and this transcription factor; in this study, we evidenced the differential expression of NeuroG1 in A549 lung adenocarcinoma cells treated with cAMP increasing agents, forskolin and IBMX. The treatment transdifferentiated A549 cells into a neuroendocrine phenotype, with neurite-like projections involving several transcription factors related to the neural differentiation, such as NEUROG1 as well as NEUROD1. The characterization of NEUROG1 as a possible biomarker for worse prognosis is important for the transdifferentiation can occur in lung adenocarcinoma under specific treatment conditions

Keywords :NeuroG1 in Lung Adenocarcinoma: Expression, Neuroendocrine Transdifferentiation, and Prognostic Implications

Conference Name :International Conference on Experimental Genetics and Genomics ICEGG-25

Conference Place Milan , UK

Conference Date 27th Sep 2025