He Worldwide Evidence Base for the Skin Substitute Integra; a Systematic Review

Author : Mohamed Elsafti

Abstract :Introduction: Integra, a widely recognised dermal regeneration template, is commonly used in burn management. Available in bilayer, single-layer, and flowable wound matrix forms, this review summarises the clinical experiences with Integra, focusing on its bilayer form across various applications and indications. Methods: A systematic literature search was conducted using the PubMed, Scopus, and Cochrane databases with terms such as "Integra" and "Dermal Regeneration Template." Studies were categorised based on area of application, study type, patient group, clinical indication, and evidence level. Results: Out of 726 initially screened articles, 251 studies focusing on bilayer Integra met the criteria. The studies covered skin, head and neck, breast, trunk, pelvis, extremities, and basic science. Study designs included 25 analytical studies (5 RCTs and 20 observational), 189 descriptive articles, and 1 systematic review. Positive outcomes were reported in 84% of studies, neutral in 14%, and negative in 2%.

Keywords :Integra, Dermal Regeneration Template, Burn Management, Bilayer Integra, Skin Reconstruction, Wound Healing, Tissue Engineering, Clinical Outcomes.

Conference Name :International Conference on Plastic, Reconstructive and Aesthetic Surgery (ICPRAS-25)

Conference Place Dublin, Ireland

Conference Date 10th Jan 2025