Nanoparticle-Based Strategies for Enhancing Oxygen Delivery in Hypoxic Tumors: Current Trends and Future Directions
Author : Kashish Bose
Abstract :Tumor hypoxia, a common feature in solid tumors, significantly impairs the efficacy of conventional therapies and contributes to aggressive cancer behavior. Recent advancements in nanotechnology offer promising strategies to enhance oxygen delivery to hypoxic tumor regions, thereby improving treatment outcomes. This review provides a comprehensive overview of current nanoparticle-based strategies aimed at addressing tumor hypoxia. We examine various approaches, including the development of oxygen-releasing nanoparticles, hypoxia-targeted drug delivery systems, and innovative nanocarriers designed to improve the pharmacokinetics and distribution of therapeutic agents. Additionally, we highlight the use of nanotechnology in enhancing the effectiveness of radiotherapy and chemotherapy by alleviating the oxygen deficiency in tumors. Recent progress in this field includes the design of stimuli-responsive nanoparticles that release oxygen in response to the acidic and hypoxic microenvironment of tumors. Despite these advancements, challenges such as nanoparticle stability, biocompatibility, and targeted delivery remain. Future directions involve the integration of multi-functional nanoplatforms that combine oxygen delivery with other therapeutic modalities, as well as the exploration of personalized nanomedicine approaches tailored to individual tumor profiles. This review aims to provide a detailed understanding of the current trends in nanoparticle-based strategies for enhancing oxygen delivery in hypoxic tumors and to outline potential future directions for research and clinical application.
Keywords :Nanoparticles, Tumor Hypoxia, Oxygen Delivery, Nanocarriers, Hypoxia-Responsive Systems, Targeted Drug Delivery.
Conference Name :International Conference on Molecular Neurobiology and Genetics (ICMNG-25)
Conference Place Moscow, Russia
Conference Date 4th Jan 2025
