Is laterality in breast Cancer still worth studying? Local experience in Bahrain

Author : Hamdi Al Shenawi , Suhair Al Saad , Amer Almarabheh , Noor Al Shenawi , Abdulla Ismaeel Mohamed, Rami Yaghan

Abstract :Background: Laterality in breast cancer means an increased frequency of left-sided breast cancers compared to right-sided breast cancers ranging between 1.05 and 1.26. It was first described in 1935 by Fellenberg, Sweden. The explanation of this phenomenon is not clear, but the association with other factors was found. This study aimed to explore the laterality of breast cancer in Bahrain as a model for Arabian countries. The association of laterality with the clinicopathological characteristics of the tumor was also analyzed to explore any applied clinical value. Methods: This is a cross-sectional, retrospective review of a particular ethnic population to study laterality of breast cancer versus a number of clinicopathological factors, as well as prognosis. The study analyzed 228 breast cancer patients treated in Arabian Gulf University facilities in Bahrain between 1999 and 2020. Three bilateral breast cancer and two malignant phyllodes patients were excluded. The following variables were analyzed: laterality ratio (Lt/Rt) and the association between laterality and clinicopathological characteristics (age at diagnosis, family history of malignancy, size of the tumor, tumor grade, histological type, hormonal receptors and HER2, axillary lymph node status, tumor stage, five-year survival rate, nulliparity, and multifocality)

Keywords :Bahrain 3, Breast cancer 1, Family history 5, Laterality 2, Size of tumor 6, Tumor stage 4

Conference Name :International Conference on General Surgery and Cancer Surgery (ICGSCS-25)

Conference Place Aarhus, Denmark

Conference Date 1st Aug 2025