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A multi-omics analysis of effector and resting Treg cells in pan-cancer

Author : Apostolos Zaravinos

Abstract :Regulatory T cells (Tregs) are critical for maintaining the stability of the immune system and facilitating tumor escape through various mechanisms. Resting T cells are involved in cell-mediated immunity and remain in a resting state until stimulated, while effector T cells promote immune responses. Here, we investigated the roles of two gene signatures, one for resting Tregs (FOXP3 and IL2RA) and another for effector Tregs (FOXP3, CTLA-4, CCR8 and TNFRSF9) in pan-cancer. Using data from The Cancer Genome Atlas (TCGA), The Cancer Proteome Atlas (TCPA) and Gene Expression Omnibus (GEO), we focused on the expression profile of the two signatures, the existence of single nucleotide variants (SNVs) and copy number variants (CNVs), methylation, infiltration of immune cells in the tumor and sensitivity to different drugs. Our analysis revealed that both signatures are differentially expressed across different cancer types, and correlate with patient survival.

Keywords :Regulatory T cells (tregs), Effector tregs, Resting tregs, FOXP3, IL2RA, CTLA-4, CCR8, TNFRSF9, Pan-cancer analysis, Immune infiltration, Gene expression, Tumor microenvironment, Drug sensitivity

Conference Name :International Conference on Computational Molecular Biology (ICCMB-25)

Conference Place Prague, Czech Republic

Conference Date 10th Jun 2025

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