Interlocking relationship between PTK2B and MAPK signaling pathway in glioma development with BRAFV600E mutation

Author : Min Wang

Abstract :BRAFV600E is a common oncogenic mutation found in various cancers. In the central nervous system, BRAFV600E is predominantly seen in pediatric low-grade gliomas (20% of pLGGs). MAPK signaling pathway is activated in tumors with BRAFV600E mutation, promoting rapid proliferation and metastasis of tumor cells. Here we identify Protein Tyrosine Kinase 2 Beta (PTK2B) or its ortholog in Drosophila, Focal adhesion kinase (Fak), as critical factor involved in human BRAFV600E-mutated glioma and dRaf GOF-induced glioma in fly brains, forming a dual regulatory axis with MAPK signaling to sustain glioma proliferation. We demonstrate a balanced relationship between PTK2B/Fak and MAPK signaling pathway in glioma cells, and inhibition of each of these two pathways suppresses tumor growth through distinct cellular processes. Currently we are investigating the specific interlocking regulatory mechanisms of these two pathways in glioma development with BRAFV600E mutation

Keywords :Glioma, BRAFV600E, PTK2B, Fak, MAPK signaling pathway

Conference Name :International Conference on Animal Genetics and Development (ICAGD-25)

Conference Place Singapore, Singapore

Conference Date 31st May 2025